Falls were reported and captured as adverse events. A time‐to‐event analysis of first fall and exposure‐adjusted subject incidence rates of falls were analyzed. The analysis was stratified by trial, and only included data from the placebo‐controlled period of each trial. The analysis included trials in women with postmenopausal osteoporosis and low bone mass, men with osteoporosis, women receiving adjuvant aromatase inhibitors for breast cancer, and men receiving androgen deprivation therapy for prostate cancer. This ad hoc exploratory analysis pooled data from five placebo‐controlled trials of denosumab to determine consistency across trials, if any, of the reduction of fall incidence. #Fallen doll 1.29 mega trial#In the pivotal placebo‐controlled fracture trial of the RANKL inhibitor denosumab in women with postmenopausal osteoporosis, treatment was associated with a lower incidence of non‐fracture‐related falls (p = 0.02). Recent studies suggest that the RANK/RANKL system impacts muscle function and/or mass. In particular, there was no evidence of interaction (p = 0.18) between baseline FRAX hip fracture probabilities and falls risk in the two arms, consistent with no impact of screening on falls in women informed to be at high risk of hip fracture.Įffectiveness of screening for high FRAX hip fracture probability to reduce hip fracture risk was not mediated by a reduction in falls. However, falls risk factors were well balanced between the study arms and, importantly, there was no evidence of a difference in falls occurrence. A higher FRAX 10-year probability of hip fracture was associated with increased likelihood of falling, with fall risk increasing by 1–2% for every 1% increase in hip fracture probability. #Fallen doll 1.29 mega free#Women sustaining one or more falls were slightly older at baseline than those remaining falls free during follow-up (mean difference 0.70 years, 95%CI 0.55–0.85, p < 0.001). We determined the influence of baseline risk factors on future falls, and then examined for differences in falls risk between the randomisation groups, particularly in those at high fracture risk. Falls were captured by self-reported questionnaire. The SCOOP study recruited 12,483 women aged 70–85 years, individually randomised to a control (n = 6250) or screening (n = 6233) arm in the latter, osteoporosis treatment was recommended to women at high risk of hip fracture, while the control arm received usual care. To investigate whether effectiveness of an osteoporosis screening programme to reduce hip fractures was mediated by modification of falls risk in the screening arm. This post hoc analysis demonstrates that identifying high hip fracture risk by FRAX was not associated with any alteration in falls risk. #Fallen doll 1.29 mega plus#However, no significant association between vitamin D2 or D3 and a reduction in the risk of falls was found (OR, 0.77 95% CI, 0.58-1.03 for vitamin D2, and OR, 1.08 95% CI, 0.98-1.20 for vitamin D3).Ĭombined calcium plus vitamin D supplementation is statistically significantly associated with a reduction in fall risks across various populations.Ī reduction in hip fracture incidence following population screening might reflect the effectiveness of anti-osteoporosis therapy, behaviour change to reduce falls, or both. The meta-analysis showed that combined vitamin D plus calcium supplementation has a significant effect on the reduction in the risk of falls (OR for the risk of suffering at least one fall, 0.87 95% CI, 0.80-0.94). We included only double-blind randomized, controlled trials (RCTs) of vitamin D in elderly populations that examined fall results.Ī total of 26 articles were included in which 16,540 elderly individuals received vitamin D supplementation, while 16,146 were assigned to control groups. Two authors working independently reviewed the trials, and odds ratios (ORs) were calculated using a fixed-effect or random-effect model by Review Manager 5.3. The PubMed and Cochrane Library databases were searched from the earliest possible year up to December 2016. We conducted this meta-analysis to assess the effect of vitamin D on falls among elderly individuals. A number of studies have hypothesized that vitamin D is a potential factor in the prevention of falls in the elderly however, the effect of vitamin D is still inconsistent and not quantitative.
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